Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release of self-ds...

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Udgivet i:Sci Rep
Main Authors: Nascimento, Mégane, Gombault, Aurélie, Lacerda-Queiroz, Norinne, Panek, Corinne, Savigny, Florence, Sbeity, Malak, Bourinet, Manon, Le Bert, Marc, Riteau, Nicolas, Ryffel, Bernhard, Quesniaux, Valérie F. J., Couillin, Isabelle
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795997/
https://ncbi.nlm.nih.gov/pubmed/31619733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51427-y
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