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NFAT primes the human RORC locus for RORγt expression in CD4(+) T cells
T helper 17 (Th17) cells have crucial functions in mucosal immunity and the pathogenesis of several chronic inflammatory diseases. The lineage-specific transcription factor, RORγt, encoded by the RORC gene modulates Th17 polarization and function, as well as thymocyte development. Here we define sev...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6795897/ https://ncbi.nlm.nih.gov/pubmed/31619674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12680-x |
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