Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

PIP(3)-dependent Rac exchanger 1 (P-Rex1) is activated downstream of G protein–coupled receptors to promote neutrophil migration and metastasis. The structure of more than half of the enzyme and its regulatory G protein binding site are unknown. Our 3.2 Å cryo-EM structure of the P-Rex1–Gβγ complex...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Cash, Jennifer N., Urata, Sarah, Li, Sheng, Ravala, Sandeep K., Avramova, Larisa V., Shost, Michael D., Gutkind, J. Silvio, Tesmer, John J. G., Cianfrocco, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795519/
https://ncbi.nlm.nih.gov/pubmed/31663027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax8855
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados