Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion

Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is an unmet need for innovative tools to block transmission in endemic areas. In t...

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Veröffentlicht in:PLoS One
Hauptverfasser: Demeu, Lara Maria Kalempa, Soares, Rodrigo Jahn, Miranda, Juliana Severo, Pacheco-Lugo, Lisandro A., Oliveira, Kelin Gonçalves, Cortez Plaza, Cristian Andrés, Billiald, Philippe, Ferreira de Moura, Juliana, Yoshida, Nobuko, Alvarenga, Larissa Magalhães, DaRocha, Wanderson Duarte
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795462/
https://ncbi.nlm.nih.gov/pubmed/31618282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223773
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