Dysregulated integrin α(V)β(3) and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis

Osteoarthritis (OA) is the leading cause of joint failure, yet the underlying mechanisms remain elusive, and no approved therapies that slow progression exist. Dysregulated integrin function was previously implicated in OA pathogenesis. However, the roles of integrin α(V)β(3) and the integrin-associ...

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Publicado en:JCI Insight
Main Authors: Wang, Qian, Onuma, Kazuhiro, Liu, Changhao, Wong, Heidi, Bloom, Michelle S., Elliott, Eileen E., Cao, Richard R.L., Hu, Nick, Lingampalli, Nithya, Sharpe, Orr, Zhao, Xiaoyan, Sohn, Dong Hyun, Lepus, Christin M., Sokolove, Jeremy, Mao, Rong, Cisar, Cecilia T., Raghu, Harini, Chu, Constance R., Giori, Nicholas J., Willingham, Stephen B., Prohaska, Susan S., Cheng, Zhen, Weissman, Irving L., Robinson, William H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795293/
https://ncbi.nlm.nih.gov/pubmed/31534047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128616
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