Dysregulated integrin α(V)β(3) and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis

Osteoarthritis (OA) is the leading cause of joint failure, yet the underlying mechanisms remain elusive, and no approved therapies that slow progression exist. Dysregulated integrin function was previously implicated in OA pathogenesis. However, the roles of integrin α(V)β(3) and the integrin-associ...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Wang, Qian, Onuma, Kazuhiro, Liu, Changhao, Wong, Heidi, Bloom, Michelle S., Elliott, Eileen E., Cao, Richard R.L., Hu, Nick, Lingampalli, Nithya, Sharpe, Orr, Zhao, Xiaoyan, Sohn, Dong Hyun, Lepus, Christin M., Sokolove, Jeremy, Mao, Rong, Cisar, Cecilia T., Raghu, Harini, Chu, Constance R., Giori, Nicholas J., Willingham, Stephen B., Prohaska, Susan S., Cheng, Zhen, Weissman, Irving L., Robinson, William H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795293/
https://ncbi.nlm.nih.gov/pubmed/31534047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128616
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