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Predictability of individual circadian phase during daily routine for medical applications of circadian clocks

BACKGROUND: Circadian timing of treatments can largely improve tolerability and efficacy in patients. Thus, drug metabolism and cell cycle are controlled by molecular clocks in each cell and coordinated by the core body temperature 24-hour rhythm, which is generated by the hypothalamic pacemaker. In...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Komarzynski, Sandra, Bolborea, Matei, Huang, Qi, Finkenstädt, Bärbel, Lévi, Francis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795290/
https://ncbi.nlm.nih.gov/pubmed/31430260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130423
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