P14.118 Carboxypeptidase G2 (CPG2) rescue after high dose methotrexate (hdMTX) chemotherapy for Primary CNS Lymphoma (PCNSL). A French LOC network study

BACKGROUND: CPG2 is an efficient rescue recombinant bacterial enzyme that cleaves MTX into inactive metabolites. As hdMTX is the key agent in PCNSL, delayed MTX excretion (DME), and/or MTX induced nephrotoxicity (MIN) may expose the patients to severe toxicities and prevent the further use of the dr...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Garcilazo, Y J, Soussain, C, Tabouret, E, Ahle, G, Schimitt, A, Waultier, A, Blonski, M, Liou-Schischmanoff, A, Hoang-Xuan, K, Houillier, C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Poster Presentations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795280/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz126.353
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