Anti-Cancer Effects of 3, 3’-Diindolylmethane on Human Hepatocellular Carcinoma Cells Is Enhanced by Calcium Ionophore: The Role of Cytosolic Ca(2+) and p38 MAPK

Purpose: 3,3′-Diindolylmethane (DIM), derived from indole-3-carbinol (I3C) in the Brassica species of cruciferous vegetables, has anticancer effects, but its exact underlying mechanism of action is unknown. We explored the roles of cytosolic free calcium ([Ca(2+)](i)) and p38 MAPK in the anti-cancer...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Jiang, Yuanyue, Fang, Yanfei, Ye, Yang, Xu, Xinming, Wang, Bingfang, Gu, Jie, Aschner, Michael, Chen, Jian, Lu, Rongzhu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795059/
https://ncbi.nlm.nih.gov/pubmed/31649538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01167
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