Ionizing radiation increases the endothelial permeability and the transendothelial migration of tumor cells through ADAM10-activation and subsequent degradation of VE-cadherin

BACKGROUND: We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of endothelial intercellular junctions, and their roles in the transmigration of c...

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Publicado en:BMC Cancer
Autores principales: Kouam, Pascaline Nguemgo, Rezniczek, Günther A., Adamietz, Irenäus A., Bühler, Helmut
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6794838/
https://ncbi.nlm.nih.gov/pubmed/31619190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6219-7
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