Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Phloretin (PH) possesses anticancer, antitumor, and hepatoprotective effects, however, the effects and potential mechanisms of phloretin remain elusive. METHODS: Five HCC cells were tested in vitro for sensitivit...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Saraswati, Sarita, Alhaider, Abdulqader, Abdelgadir, Abdelgalil Mohamed, Tanwer, Pooja, Korashy, Hesham M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6794763/
https://ncbi.nlm.nih.gov/pubmed/31619257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0430-7
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