Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism

Human primary aldosteronism (PA) can be caused by mutations in several ion channel genes but mouse models replicating this condition are lacking. We now show that almost all known PA-associated CLCN2 mutations markedly increase ClC-2 chloride currents and generate knock-in mice expressing a constitu...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Göppner, Corinna, Orozco, Ian J., Hoegg-Beiler, Maja B., Soria, Audrey H., Hübner, Christian A., Fernandes-Rosa, Fabio L., Boulkroun, Sheerazed, Zennaro, Maria-Christina, Jentsch, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6794291/
https://ncbi.nlm.nih.gov/pubmed/31615979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12113-9
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