Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations

Locomotor activity is a polygenic trait that varies widely among inbred strains of mice (Flint et al., 1995). To characterize the role of D2 dopamine receptors in locomotion, we generated F(2)hybrid (129/Sv × C57BL/6) D2 dopamine receptor (D2R)-deficient mice by gene targeting and investigated the c...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Kelly, Michele A., Rubinstein, Marcelo, Phillips, Tamara J., Lessov, Christina N., Burkhart-Kasch, Sue, Zhang, Ge, Bunzow, James R., Fang, Yuan, Gerhardt, Gregory A., Grandy, David K., Low, Malcolm J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792649/
https://ncbi.nlm.nih.gov/pubmed/9547254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-09-03470.1998
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