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N(10)‐carbonyl‐substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress

During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified. Subsequent tests revealed the compounds act by inhibiting lipid peroxidation, a trigger for a form of regulated cell death known as ferroptosis....

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Detalhes bibliográficos
Publicado no:Chem Biol Drug Des
Main Authors: Keynes, Robert G., Karchevskaya, Anastasia, Riddall, Dieter, Griffiths, Charmaine H., Bellamy, Tomas C., Chan, A. W. Edith, Selwood, David L., Garthwaite, John
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790564/
https://ncbi.nlm.nih.gov/pubmed/31127979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13572
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