(64)Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer

PURPOSE: Therapeutic nanoparticles are designed to deliver their drug payloads through enhanced permeability and retention (EPR) in solid tumors. The extent of EPR and its variability in human tumors is highly debated and has been proposed as an explanation for variable responses to therapeutic nano...

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Publié dans:Clin Cancer Res
Auteurs principaux: Lee, Helen, Shields, Anthony F., Siegel, Barry A., Miller, Kathy, Krop, Ian, Ma, Cynthia, LoRusso, Patricia M., Munster, Pamela, Campbell, Karen, Gaddy, Daniel F., Leonard, Shannon C., Geretti, Elena, Blocker, Stephanie, Kirpotin, Dmitri, Moyo, Victor, Wickham, Thomas, Hendriks, Bart S.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790129/
https://ncbi.nlm.nih.gov/pubmed/28298546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-3193
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