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SDS22 selectively recognizes and traps metal-deficient inactive PP1

The metalloenzyme protein phosphatase 1 (PP1), which is responsible for ≥50% of all dephosphorylation reactions, is regulated by scores of regulatory proteins, including the highly conserved SDS22 protein. SDS22 has numerous diverse functions, surprisingly acting as both a PP1 inhibitor and as an ac...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Choy, Meng S., Moon, Thomas M., Ravindran, Rini, Bray, Johnny A., Robinson, Lucy C., Archuleta, Tara L., Shi, Wuxian, Peti, Wolfgang, Tatchell, Kelly, Page, Rebecca
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789808/
https://ncbi.nlm.nih.gov/pubmed/31548429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908718116
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