Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion

The 3q29 deletion confers increased risk for neuropsychiatric phenotypes including intellectual disability, autism spectrum disorder, generalized anxiety disorder, and a >40-fold increased risk for schizophrenia. To investigate consequences of the 3q29 deletion in an experimental system, we used...

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Udgivet i:Mol Psychiatry
Main Authors: Rutkowski, Timothy P., Purcell, Ryan H., Pollak, Rebecca M., Grewenow, Stephanie M., Gafford, Georgette M., Malone, Tamika, Khan, Uswa A., Schroeder, Jason P., Epstein, Michael P., Bassell, Gary J., Warren, Stephen T., Weinshenker, David, Caspary, Tamara, Mulle, Jennifer Gladys
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788962/
https://ncbi.nlm.nih.gov/pubmed/30976085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0413-5
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