Propofol Induces Cardioprotection Against Ischemia-Reperfusion Injury via Suppression of Transient Receptor Potential Vanilloid 4 Channel

Ca(2+) entry via the transient receptor potential vanilloid 4 (TRPV4) channel contributes to Ca(2+) overload and triggers many pathophysiological conditions, including myocardial ischemia/reperfusion (I/R) injury. Propofol, a widely used intravenous anesthetic, attenuates myocardial I/R injury. Howe...

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Vydáno v:Front Pharmacol
Hlavní autoři: Wang, Binbin, Wu, Qiongfeng, Liao, Jie, Zhang, Shaoshao, Liu, Huixia, Yang, Cui, Dong, Qian, Zhao, Ning, Huang, Zhengrong, Guo, Kefang, Du, Yimei
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788301/
https://ncbi.nlm.nih.gov/pubmed/31636563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01150
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