Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer

BACKGROUND: Mcl-1, an anti-apoptotic member of bcl-2 family, together with cleaved poly (ADC-ribose) polymerase (c-PARP) can serve as a marker of cell apoptosis. Previously we reported that treatment of Mnk inhibitor CGP57380 resulted in decreased Mcl-1 expression while increased c-PARP expression i...

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Detalhes bibliográficos
Publicado no:Diagn Pathol
Main Authors: Wen, Qiuyuan, Zhan, Yuting, Zheng, Hongmei, Zang, Hongjing, Luo, Jiadi, Zhang, Yuting, Wang, Weiyuan, Feng, Juan, Lu, Junmi, Chen, Lingjiao, Fan, Songqing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788105/
https://ncbi.nlm.nih.gov/pubmed/31601252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13000-019-0884-3
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