IL27Rα Deficiency Alters Endothelial Cell Function and Subverts Tumor Angiogenesis in Mammary Carcinoma

IL-27 regulates inflammatory diseases by exerting a pleiotropic impact on immune cells. In cancer, IL-27 restricts tumor growth by acting on tumor cells directly, while its role in the tumor microenvironment is still controversially discussed. To explore IL-27 signaling in the tumor stroma, we used...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Fink, Annika F., Ciliberti, Giorgia, Popp, Rüdiger, Sirait-Fischer, Evelyn, Frank, Ann-Christin, Fleming, Ingrid, Sekar, Divya, Weigert, Andreas, Brüne, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787910/
https://ncbi.nlm.nih.gov/pubmed/31637217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01022
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