Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen

Dendritic cells (DCs) are important initiators of adaptive immunity, and they possess a multitude of Pattern Recognition Receptors (PRR) to generate an adequate T cell mediated immunity against invading pathogens. PRR ligands are frequently conjugated to tumor-associated antigens in a vaccination st...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Chem
Auteurs principaux: Li, Rui-Jun Eveline, Hogervorst, Tim P., Achilli, Silvia, Bruijns, Sven C., Arnoldus, Tim, Vivès, Corinne, Wong, Chung C., Thépaut, Michel, Meeuwenoord, Nico J., van den Elst, Hans, Overkleeft, Herman S., van der Marel, Gijs A., Filippov, Dmitri V., van Vliet, Sandra J., Fieschi, Franck, Codée, Jeroen D. C., van Kooyk, Yvette
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Chemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787163/
https://ncbi.nlm.nih.gov/pubmed/31637232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00650
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