Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD(+) in medium-chain acyl-CoA dehydrogenase knockout mice

During fasting, mitochondrial fatty-acid β-oxidation (mFAO) is essential for the generation of glucose by the liver. Children with a loss-of-function deficiency in the mFAO enzyme medium-chain acyl-Coenzyme A dehydrogenase (MCAD) are at serious risk of life-threatening low blood glucose levels durin...

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Publicado no:Sci Rep
Main Authors: Martines, Anne-Claire M. F., Gerding, Albert, Stolle, Sarah, Vieira-Lara, Marcel A., Wolters, Justina C., Jurdzinski, Angelika, Bongiovanni, Laura, de Bruin, Alain, van der Vlies, Pieter, van der Vries, Gerben, Bloks, Vincent W., Derks, Terry G. J., Reijngoud, Dirk-Jan, Bakker, Barbara M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787083/
https://ncbi.nlm.nih.gov/pubmed/31601874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50758-0
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