Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA

Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to evade host immunity. This poses a significant challenge for the host to develop broadly neutralizing antibodies. In Plasmodium falciparum, we show that a mechanism to circumvent this challenge is to elicit antib...

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Vydáno v:mBio
Hlavní autoři: Mitran, Catherine J., Mena, Angie, Gnidehou, Sedami, Banman, Shanna, Arango, Eliana, Lima, Barbara A. S., Lugo, Hazel, Ganesan, Aravindhan, Salanti, Ali, Mbonye, Anthony K., Ntumngia, Francis, Barakat, Khaled, Adams, John H., Kano, Flora S., Carvalho, Luzia H., Maestre, Amanda E., Good, Michael F., Yanow, Stephanie K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786876/
https://ncbi.nlm.nih.gov/pubmed/31594821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02343-19
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