Metformin promotes antitumor immunity via endoplasmic reticulum-associated degradation of PD-L1

Metformin has been reported to possess antitumor activity and maintain high cytotoxic T lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of metformin’s role in cancer immunity are not fully understood. Here we show metformin increases CTL activity by reducing the...

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Publicado no:Mol Cell
Main Authors: Cha, Jong-Ho, Yang, Wen-Hao, Xia, Weiya, Wei, Yongkun, Chan, Li-Chuan, Lim, Seung-Oe, Li, Chia-Wei, Kim, Taewan, Chang, Shih-Shin, Lee, Heng-Huan, Hsu, Jennifer L., Wang, Hung-Ling, Kuo, Chu-Wei, Chang, Wei-Chao, Hadad, Sirwan, Purdie, Colin A., McCoy, Aaron M., Cai, Shirong, Tu, Yizheng, Litton, Jennifer K., Mittendorf, Elizabeth A., Moulder, Stacy L., Symmans, William F, Thompson, Alastair M., Piwnica-Worms, Helen, Chen, Chung-Hsuan, Khoo, Kay-Hooi, Hung, Mien-Chie
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786495/
https://ncbi.nlm.nih.gov/pubmed/30118680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.07.030
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