Paeoniflorin-6′-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents

Paeoniflorin-6′-O-benzene sulfonate (CP-25) is a new ester derivative of paeoniflorin with improved lipid solubility and oral bioavailability, as well as better anti-inflammatory activity than its parent compound. In this study we explored whether CP-25 exerted therapeutic effects in collagen-induce...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Shu, Jin-ling, Zhang, Xian-zheng, Han, Le, Zhang, Feng, Wu, Yu-jing, Tang, Xiao-yu, Wang, Chen, Tai, Yu, Wang, Qing-tong, Chen, Jing-yu, Chang, Yan, Wu, Hua-xun, Zhang, Ling-ling, Wei, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786314/
https://ncbi.nlm.nih.gov/pubmed/30446734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0169-5
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