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The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery

Herein, we disclose the development of a synthetic route to gain access to the uvaretin class of chalcone natural products. In this, the construction of a small library was achieved, and the collection was evaluated for cytotoxicity and other biological properties. Uvaretin (1) was accessed via a se...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Medchemcomm
Hauptverfasser: Dallman, Johnathan, Lansakara, Ashabha, Nguyen, Thi, Weeramange, Chamitha, Hulangamuwa, Wasundara, Rafferty, Ryan J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786243/
https://ncbi.nlm.nih.gov/pubmed/31673309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00052f
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