Interleukin-1 Mediates a Rapid Inflammatory Response After Injection of Adenoviral Vectors into the Brain

Adenovirus-mediated gene transfer into the brain is associated with significant inflammation and activation of anti-vector and anti-transgene immune responses that curtail the gene delivery of adenoviruses and therapeutic efficacy. Elucidating the molecular mediators of inflammatory and immune respo...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Cartmell, Tammy, Southgate, Tom, Rees, Gwen S., Castro, Maria G., Lowenstein, Pedro R., Luheshi, Giamal N.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 1999
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786017/
https://ncbi.nlm.nih.gov/pubmed/9952427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-04-01517.1999
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