Efficacy of Typhoid Conjugate Vaccine in Nepal: An Interim Analysis of a Participant-and Observer-Blinded Randomized Phase III Trial

BACKGROUND: Salmonella Typhi is a major cause of fever in children in low- and middle-income countries. The recently WHO prequalified typhoid conjugate vaccine (TCV) was shown to be efficacious in a human challenge model but no efficacy trials in endemic populations have been completed. METHODS: In...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:N Engl J Med
Prif Awduron: Shakya, Mila, Colin-Jones, Rachel, Theiss-Nyland, Katherine, Voysey, Merryn, Pant, Dikshya, Smith, Nicola, Liu, Xinxue, Tonks, Susan, Mazur, Olga, Farooq, Yama G., Clarke, Jenny, Hill, Jennifer, Adhikari, Anup, Dongol, Sabina, Karkey, Abhilasha, Bajracharya, Binod, Kelly, Sarah, Gurung, Meeru, Baker, Stephen, Neuzil, Kathleen M., Shrestha, Shrijana, Basnyat, Buddha, Pollard, Andrew J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Massachusetts Medical Society 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785806/
https://ncbi.nlm.nih.gov/pubmed/31800986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1905047
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