Efficacy of Typhoid Conjugate Vaccine in Nepal: An Interim Analysis of a Participant-and Observer-Blinded Randomized Phase III Trial

BACKGROUND: Salmonella Typhi is a major cause of fever in children in low- and middle-income countries. The recently WHO prequalified typhoid conjugate vaccine (TCV) was shown to be efficacious in a human challenge model but no efficacy trials in endemic populations have been completed. METHODS: In...

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Publicado no:N Engl J Med
Main Authors: Shakya, Mila, Colin-Jones, Rachel, Theiss-Nyland, Katherine, Voysey, Merryn, Pant, Dikshya, Smith, Nicola, Liu, Xinxue, Tonks, Susan, Mazur, Olga, Farooq, Yama G., Clarke, Jenny, Hill, Jennifer, Adhikari, Anup, Dongol, Sabina, Karkey, Abhilasha, Bajracharya, Binod, Kelly, Sarah, Gurung, Meeru, Baker, Stephen, Neuzil, Kathleen M., Shrestha, Shrijana, Basnyat, Buddha, Pollard, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: Massachusetts Medical Society 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785806/
https://ncbi.nlm.nih.gov/pubmed/31800986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1905047
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