Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving

Neuroadaptations in the nucleus accumbens (NAc) underlie cue-induced cocaine craving that intensifies (“incubates”) during abstinence and is believed to contribute to persistent relapse vulnerability. Changes in gene expression often govern perpetual behavioral abnormalities, but epigenetic plastici...

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Udgivet i:Sci Adv
Main Authors: Werner, C. T., Mitra, S., Martin, J. A., Stewart, A. F., Lepack, A. E., Ramakrishnan, A., Gobira, P. H., Wang, Z.-J., Neve, R. L., Gancarz, A. M., Shen, L., Maze, I., Dietz, D. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785264/
https://ncbi.nlm.nih.gov/pubmed/31633032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay0351
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