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Ultraslow Domain Motions in HIV-1 TAR RNA Revealed by Solid-State Deuterium NMR

Intrinsic motions allow HIV-1 TAR RNA to change its conformation to form a functional complex with the Tat protein, which is essential for viral replication. Understanding of the dynamic properties of TAR necessitates determining motion on the intermediate ns-μs time scale. To this end, we performed...

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Pubblicato in:J Phys Chem B
Autori principali: Huang, Wei, Emani, Prashant S., Varani, Gabriele, Drobny, Gary P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785184/
https://ncbi.nlm.nih.gov/pubmed/27930881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b11041
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