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Impaired instrumental reversal learning is associated with increased medial prefrontal cortex activity in Sapap3 knockout mouse model of compulsive behavior

Convergent functional neuroimaging findings implicate hyperactivity across the prefrontal cortex (PFC) and striatum in the neuropathology of obsessive compulsive disorder (OCD). The impact of cortico-striatal circuit hyperactivity on executive functions subserved by these circuits is unclear, becaus...

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Bibliografiske detaljer
Udgivet i:Neuropsychopharmacology
Main Authors: Manning, Elizabeth E., Dombrovski, Alexandre Y., Torregrossa, Mary M., Ahmari, Susanne E.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785097/
https://ncbi.nlm.nih.gov/pubmed/30587851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0307-2
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