The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies

The 5′-deoxyadenosyl radical (5′-dAdo·) abstracts a substrate H atom as the first step in radical-based transformations catalyzed by adenosylcobalamin-dependent and radical S-adenosyl-L-methionine (RS) enzymes. Notwithstanding its central biological role, 5′-dAdo· has eluded characterization despite...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Yang, Hao, McDaniel, Elizabeth C., Impano, Stella, Byer, Amanda S., Jodts, Richard J., Yokoyama, Kenichi, Broderick, William E., Broderick, Joan B., Hoffman, Brian M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784836/
https://ncbi.nlm.nih.gov/pubmed/31274303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b05926
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