Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease

Microcystins are potent hepatotoxins that have become a global health concern in recent years. Their actions in at-risk populations with pre-existing liver disease is unknown. We tested the hypothesis that the No Observed Adverse Effect Level (NOAEL) of Microcystin-LR (MC-LR) established in healthy...

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Udgivet i:Toxins (Basel)
Main Authors: Lad, Apurva, Su, Robin C., Breidenbach, Joshua D., Stemmer, Paul M., Carruthers, Nicholas J., Sanchez, Nayeli K., Khalaf, Fatimah K., Zhang, Shungang, Kleinhenz, Andrew L., Dube, Prabhatchandra, Mohammed, Chrysan J., Westrick, Judy A., Crawford, Erin L., Palagama, Dilrukshika, Baliu-Rodriguez, David, Isailovic, Dragan, Levison, Bruce, Modyanov, Nikolai, Gohara, Amira F., Malhotra, Deepak, Haller, Steven T., Kennedy, David J.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783870/
https://ncbi.nlm.nih.gov/pubmed/31450746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins11090486
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