Continuous Subcutaneous Delivery of Proline-Rich Antimicrobial Peptide Api137 Provides Superior Efficacy to Intravenous Administration in a Mouse Infection Model

Apidaecins are cationic, proline-rich antimicrobial peptides originally isolated from honeybees and exhibit high Gram-negative activity by inhibiting bacterial protein translation. Pharmacokinetics of apidaecin derivative Api137 was studied using single and multiple intravenous or subcutaneous injec...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Knappe, Daniel, Schmidt, Rico, Adermann, Knut, Hoffmann, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783563/
https://ncbi.nlm.nih.gov/pubmed/31632382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.02283
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