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Stereotyped transcriptomic transformation of somatosensory neurons in response to injury

In mice, spared nerve injury replicates symptoms of human neuropathic pain and induces upregulation of many genes in somatosensory neurons. Here we used single cell transcriptomics to probe the effects of partial infraorbital transection of the trigeminal nerve at the cellular level. Uninjured neuro...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Nguyen, Minh Q, Le Pichon, Claire E, Ryba, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783272/
https://ncbi.nlm.nih.gov/pubmed/31592768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49679
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