Impairments in High-Frequency Transmission, Synaptic Vesicle Docking, and Synaptic Protein Distribution in the Hippocampus of BDNF Knockout Mice

Brain-derived neurotrophic factor (BDNF) promotes long-term potentiation (LTP) at hippocampal CA1 synapses by a presynaptic enhancement of synaptic transmission during high-frequency stimulation (HFS). Here we have investigated the mechanisms of BDNF action using two lines of BDNF knockout mice. Amo...

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Published in:J Neurosci
Main Authors: Pozzo-Miller, Lucas D., Gottschalk, Wolfram, Zhang, Li, McDermott, Kathryn, Du, Jing, Gopalakrishnan, Raj, Oho, Chikara, Sheng, Zu-Hang, Lu, Bai
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 1999
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782660/
https://ncbi.nlm.nih.gov/pubmed/10366630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-12-04972.1999
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