Saccharomyces cerevisiae Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding

Two common features of centromeres are their transcription into noncoding centromere RNAs (cen-RNAs) and their assembly into nucleosomes that contain a centromere-specific histone H3 (cenH3). Here, we show that Saccharomyces cerevisiae cen-RNA was present in low amounts in wild-type (WT) cells, and...

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Veröffentlicht in:Genetics
Hauptverfasser: Chen, Chi-Fu, Pohl, Thomas J., Chan, Angela, Slocum, Joshua S., Zakian, Virginia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Genetics Society of America 2019
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Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781895/
https://ncbi.nlm.nih.gov/pubmed/31391265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.302528
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