Hair follicle regeneration suppresses Ras-driven oncogenic growth

Mutations associated with tumor development in certain tissues can be nontumorigenic in others, yet the mechanisms underlying these different outcomes remains poorly understood. To address this, we targeted an activating Hras mutation to hair follicle stem cells and discovered that Hras mutant cells...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Pineda, Cristiana M., Gonzalez, David G., Matte-Martone, Catherine, Boucher, Jonathan, Lathrop, Elizabeth, Gallini, Sara, Fons, Nathan R., Xin, Tianchi, Tai, Karen, Marsh, Edward, Nguyen, Don X., Suozzi, Kathleen C., Beronja, Slobodan, Greco, Valentina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781447/
https://ncbi.nlm.nih.gov/pubmed/31488583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201907178
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