Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56

During mitosis, the formation of microtubule–kinetochore attachments is monitored by the serine/threonine kinase monopolar spindle 1 (MPS1). MPS1 is recruited to unattached kinetochores where it phosphorylates KNL1, BUB1, and MAD1 to initiate the spindle assembly checkpoint. This arrests the cell cy...

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Опубликовано в: :J Cell Biol
Главные авторы: Hayward, Daniel, Bancroft, James, Mangat, Davinderpreet, Alfonso-Pérez, Tatiana, Dugdale, Sholto, McCarthy, Julia, Barr, Francis A., Gruneberg, Ulrike
Формат: Artigo
Язык:Inglês
Опубликовано: Rockefeller University Press 2019
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781431/
https://ncbi.nlm.nih.gov/pubmed/31511308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201905026
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