A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice

BACKGROUND: Mouse NOTCH1 carries a highly conserved O-fucose glycan at Thr466 in epidermal growth factor-like repeat 12 (EGF12) of the extracellular domain. O-Fucose at this site has been shown by X-ray crystallography to be recognized by both DLL4 and JAG1 Notch ligands. We previously showed that a...

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Publicat a:BMC Dev Biol
Autors principals: Varshney, Shweta, Wei, Hua-Xing, Batista, Frank, Nauman, Mohd, Sundaram, Subha, Siminovitch, Katherine, Tanwar, Ankit, Stanley, Pamela
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781419/
https://ncbi.nlm.nih.gov/pubmed/31590629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12861-019-0199-3
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