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A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice
BACKGROUND: Mouse NOTCH1 carries a highly conserved O-fucose glycan at Thr466 in epidermal growth factor-like repeat 12 (EGF12) of the extracellular domain. O-Fucose at this site has been shown by X-ray crystallography to be recognized by both DLL4 and JAG1 Notch ligands. We previously showed that a...
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| Publicado no: | BMC Dev Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6781419/ https://ncbi.nlm.nih.gov/pubmed/31590629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12861-019-0199-3 |
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