Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

Both α-tryptase and β-tryptase are preferentially expressed by human mast cells, but the purpose of α-tryptase is enigmatic, because its tetramers lack protease activity, whereas β-tryptase tetramers are active proteases. The monogenic disorder called hereditary α-tryptasemia, due to increased α-try...

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Publicat a:J Exp Med
Autors principals: Le, Quang T., Lyons, Jonathan J., Naranjo, Andrea N., Olivera, Ana, Lazarus, Robert A., Metcalfe, Dean D., Milner, Joshua D., Schwartz, Lawrence B.
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780998/
https://ncbi.nlm.nih.gov/pubmed/31337736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190701
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