特异性人工抗原提呈细胞体外激活CD19嵌合抗原受体T细胞的构建

OBJECTIVE: To construct CD19-specific artificial antigen-presenting cells (aAPCs) for in vitro activation and expansion of CD19 chimeric antigen receptor (CAR)-modified T cells (CD19-CAR-T) and investigate their cytotoxic effect. METHODS: CD19-specific aAPCs (NIH3T3-CD19/86, NIH3T3-CD19/86/137L) exp...

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Bibliographic Details
Published in:Nan Fang Yi Ke Da Xue Xue Bao
Format: Artigo
Language:Inglês
Published: 南方医科大学学报编辑部 2017
Subjects:
基础研究
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780484/
https://ncbi.nlm.nih.gov/pubmed/28539278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3969/j.issn.1673-4254.2017.05.03
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