A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo

The protein Deleted in Breast Cancer-1 is a regulator of several transcription factors and epigenetic regulators, including HDAC3, Rev-erb-alpha, PARP1 and SIRT1. It is well known that DBC1 regulates its targets, including SIRT1, by protein-protein interaction. However, little is known about how DBC...

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Udgivet i:Sci Rep
Main Authors: Santos, Leonardo, Colman, Laura, Contreras, Paola, Chini, Claudia C., Carlomagno, Adriana, Leyva, Alejandro, Bresque, Mariana, Marmisolle, Inés, Quijano, Celia, Durán, Rosario, Irigoín, Florencia, Prieto-Echagüe, Victoria, Vendelbo, Mikkel H., Sotelo-Silveira, José R., Chini, Eduardo N., Badano, Jose L., Calliari, Aldo J., Escande, Carlos
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779753/
https://ncbi.nlm.nih.gov/pubmed/31591441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50789-7
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