Alternatively spliced variants of the 5’-UTR of the ARPC2 mRNA regulate translation by an internal ribosome entry site (IRES) harboring a guanine-quadruplex motif

The 5ʹ-UTR of the actin-related protein 2/3 complex subunit 2 (ARPC2) mRNA exists in two variants. Using a bicistronic reporter construct, the present study demonstrates that the longer variant of the 5ʹ-UTR harbours an internal ribosome entry site (IRES) which is lacking in the shorter one. Multipl...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Al-Zeer, Munir A., Dutkiewicz, Mariola, von Hacht, Annekathrin, Kreuzmann, Denise, Röhrs, Viola, Kurreck, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779386/
https://ncbi.nlm.nih.gov/pubmed/31387452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2019.1652524
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