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Effects of Selonsertib in Patients with Diabetic Kidney Disease
BACKGROUND: Apoptosis signal-regulating kinase 1 (ASK1) activation in glomerular and tubular cells resulting from oxidative stress may drive kidney disease progression. Findings in animal models identified selonsertib, a selective ASK1 inhibitor, as a potential therapeutic agent. METHODS: In a phase...
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| Publicat a: | J Am Soc Nephrol |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Nephrology
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6779369/ https://ncbi.nlm.nih.gov/pubmed/31506292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018121231 |
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