Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor

Feline infectious peritonitis (FIP) is a highly fatal disease caused by a virulent feline coronavirus in domestic and wild cats. We have previously reported the synthesis of potent coronavirus 3C-like protease (3CLpro) inhibitors and the efficacy of a protease inhibitor, GC376, in client-owned cats...

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Bibliographische Detailangaben
Veröffentlicht in:Vet Microbiol
Hauptverfasser: Perera, Krishani Dinali, Rathnayake, Athri D., Liu, Hongwei, Pedersen, Niels C., Groutas, William C., Chang, Kyeong-Ok, Kim, Yunjeong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier B.V. 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779346/
https://ncbi.nlm.nih.gov/pubmed/31585653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vetmic.2019.108398
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