Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel

Filariae are parasitic nematodes that are transmitted to their definitive host as third-stage larvae by arthropod vectors like mosquitoes. Filariae cause diseases including: lymphatic filariasis with distressing and disturbing symptoms like elephantiasis; and river blindness. Filarial diseases affec...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Kashyap, Sudhanva S., Verma, Saurabh, Voronin, Denis, Lustigman, Sara, Kulke, Daniel, Robertson, Alan P., Martin, Richard J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779273/
https://ncbi.nlm.nih.gov/pubmed/31553770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008041
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