A New Antisense Phosphoryl Guanidine Oligo-2′-O-Methylribonucleotide Penetrates Into Intracellular Mycobacteria and Suppresses Target Gene Expression

The worldwide spread of multidrug-resistant Mycobacterium tuberculosis strains prompted the development of new strategies to combat tuberculosis, one of which is antisense therapy based on targeting bacterial mRNA by oligonucleotide derivatives. However, the main limitation of antisense antibacteria...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Skvortsova, Yulia V., Salina, Elena G., Burakova, Ekaterina A., Bychenko, Oksana S., Stetsenko, Dmitry A., Azhikina, Tatyana L.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778816/
https://ncbi.nlm.nih.gov/pubmed/31632266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01049
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