An LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

INTRODUCTION: Noise-induced hearing loss (NIHL) is an increasing problem in society and accounts for a third of all cases of acquired hearing loss. NIHL is caused by formation of reactive oxygen species (ROS) in the cochlea causing oxidative stress. Hydrogen gas (H(2)) can alleviate the damage cause...

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Bibliografski detalji
Izdano u:Metabolomics
Glavni autori: Pirttilä, Kristian, Videhult Pierre, Pernilla, Haglöf, Jakob, Engskog, Mikael, Hedeland, Mikael, Laurell, Göran, Arvidsson, Torbjörn, Pettersson, Curt
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2019
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Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778533/
https://ncbi.nlm.nih.gov/pubmed/31587113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11306-019-1595-1
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