Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

The conversion of endogenous alpha-synuclein (asyn) to pathological asyn-enriched aggregates is a hallmark of Parkinson’s disease (PD). These inclusions can be detected in the central and enteric nervous system (ENS). Moreover, gastrointestinal symptoms can appear up to 20 years before the diagnosis...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Neuropathol
Prif Awduron: Van Den Berge, Nathalie, Ferreira, Nelson, Gram, Hjalte, Mikkelsen, Trine Werenberg, Alstrup, Aage Kristian Olsen, Casadei, Nicolas, Tsung-Pin, Pai, Riess, Olaf, Nyengaard, Jens Randel, Tamgüney, Gültekin, Jensen, Poul Henning, Borghammer, Per
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2019
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778265/
https://ncbi.nlm.nih.gov/pubmed/31254094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02040-w
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