CUDC-907 reverses pathological phenotype of keloid fibroblasts in vitro and in vivo via dual inhibition of PI3K/Akt/mTOR signaling and HDAC2

Keloids are benign skin tumors with a high recurrence rate following surgical excision. Abnormal intracellular signaling is one of the key mechanisms involved in its pathogenesis. Over-activated phosphoinositide 3-kinase/RAC-alpha serine/threonine-protein kinase/mammalian target of rapamycin (PI3K/A...

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Publicado no:Int J Mol Med
Main Authors: Tu, Tian, Huang, Jia, Lin, Miaomiao, Gao, Zhen, Wu, Xiaoli, Zhang, Wenjie, Zhou, Guangdong, Wang, Wenbo, Liu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777681/
https://ncbi.nlm.nih.gov/pubmed/31545402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2019.4348
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